Table 5. Correlation analysis of the three SNPs of ABCB1 gene and DNA methylation levels in all malaria cases and controls.
| Genotype | Subjects | Mean Methylation (%) | Range Methylation (%) | p–valuea | |
|---|---|---|---|---|---|
| All malaria cases | |||||
| rs1128503 | CC | 19 | 22.40 | 5.2–59.7 | 0.02 |
| CT | 16 | 27.32 | 6.8–57.8 | ||
| TT | 5 | 6.66 | 2.4–11.2 | ||
| rs2032582 | GG | 18 | 26.06 | 5.2–59.7 | 0.02 |
| GT | 17 | 23.16 | 5.9–57.4 | ||
| TT | 5 | 6.66 | 2.4–11.2 | ||
| rs1045642 | CC | 7 | 31.26 | 9.0–59.7 | 0.22 |
| CT | 12 | 21.63 | 6.8–57.3 | ||
| TT | 21 | 19.89 | 2.4–57.8 | ||
| Controls | |||||
| rs1128503 | CC | 19 | 41.5386 | 3.3–85.0 | 0.23 |
| CT | 15 | 36.82 | 4.0–85.5 | ||
| TT | 6 | 58.77222 | 1.9–86.7 | ||
| rs2032582 | GG | 27 | 43.06543 | 3.3–85.5 | 0.06 |
| GT | 7 | 24.87143 | 1.9–84.5 | ||
| TT | 6 | 59.55 | 6.6–86.7 | ||
| rs1045642 | CC | 6 | 54.80556 | 6.6–85.5 | 0.48 |
| CT | 14 | 43.43333 | 4.5–84.1 | ||
| TT | 20 | 37.86333 | 1.9–86.7 | ||
a Kruskal-Wallis p value < 0.05 considered to be significant.