Fig 1. Schematic representation of the modelled mFAO pathway in rat.

Metabolites in blue are fixed parameters, while other metabolites are free variables. The sum of variable CoA esters and free CoA is a conserved moiety. Green: enzymes participating in the carnitine cycle; purple: enzymes participating in the short-chain branch; grey: enzymes participating in the medium-and long-chain branch. All processes are reversible and the size of the arrowheads indicates the net direction of the flux. This model is exactly the same as published before [8], without modifications.