Fig 5. Regulation of key reactions by their substrates and products.

(A-F) Relative average absolute contribution, i.e. $\frac{{\left|\overline{\mathit{\Theta }}\right|}_{{\mathit{X}}_{\mathit{j}}}^{\mathit{v}}}{{\sum }_{\mathit{j}}{\left|\overline{\mathit{\Theta }}\right|}_{{\mathit{X}}_{\mathit{j}}}^{\mathit{v}}}\bullet \mathbf{100}\mathrm{\%}$, of metabolites to the transition from the steady state at 0.1 μM to the indicated concentration of palmitoyl-CoA, calculated for vMCKATC6 (panel A), vMCKATC4 (panel B), vMCADC6 (panel C), vSCADC4 (panel D), vMPTC8 (panel E), vCPT2C16 (panel F).