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. 2016 Jun 9;3(2):11. doi: 10.3390/vetsci3020011

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© 2016 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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The histologic features of human and canine follicular lymphoma (A–C, human and D–F, canine). Architecturally, in both species, the disease is nodular (A, C) and the neoplastic follicles lack germinal center polarization (gray arrow, B and E). Morphologically, the tumor infiltrate in both species is bimorphic, composed of predominantly smaller neoplastic centrocytes (black arrow, C and F) and rare admixed larger neoplastic centroblasts (white arrow, C and F). By flow cytometry, the neoplastic cells in human FL (colored black) are light chain restricted (G), CD10+, variably CD19+ (H), CD20+, CD45+ (I), but CD5−, and are intermediate size by forward light scatter (J).