Figure 2.

GNM-predicted mobilities of chromosomal loci in GM12878 show good agreement with data from chromatin accessibility experiments. (A–C) Mobility profiles (MSFs of loci) obtained from GNM analysis of the equilibrium dynamics of chromosomes 1, 17 and X, respectively, shown in blue, are compared to the DNA accessibilities probed by ATAC-seq (yellow) and DNA-seq (red) experiments. GNM results are based on 500 slowest modes. r₁ is the Spearman correlations between GNM predictions and DNase-seq experiments; and r₂ is that between GNM and ATAC-seq. (D) Spearman correlations between theory and experiments for all chromosomes (red and yellow bars, as labeled). The Spearman correlation between the computed MSFs and experimental ATAC-seq data averaged over all chromosomes is 0.55 ± 0.11, and that between MSFs and DNase-seq data is 0.80 ± 0.04. For comparison, we also display the Spearman correlation between the two sets of experimental data (brown bars); the average in this case is 0.70 ± 0.08.