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Pol β searches DNA using a hopping mechanism. (A) The Fp values for substrates containing 1-nt gaps on opposing strands (P20-OP) and with a small molecule roadblock (P20-RB) are compared to a substrate with 1-nt gaps on the same strand (P20). (B) The Fp values were measured at 100 mM and 200 mM ionic strengths. The mean and standard deviation is reported from three independent experiments.
