Figure 1.

Overall structure of Bacillus halodurans FadR. (A) Cartoon representation of the B. halodurans FadR dimer. The monomers are colored in cyan and yellow. The DBDs are shown in dark cyan and dark yellow. Palmitic acids are drawn in green stick models. The N and C termini are labeled. (B) Close-up view of ligand binding site in B. halodurans FadR. Residues in hydrophobic core and hydrophilic patch are shown as cyan and blue sticks, respectively. (C) Sequence alignment of B. halodurans FadR and representative TetR family FadR proteins (B. subtilis and Thermus thermophilus). Every 20th residue is indicated above the sequence of B. halodurans FadR. Highly conserved residues and partially conserved residues are shaded in black and gray, respectively. The residues involved in DNA binding and ligand binding are indicated as red and blue triangles.