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. 2016 Dec 19;45(7):4131–4141. doi: 10.1093/nar/gkw1284

Figure 3.

Figure 3.

Engulfed miR-223-3p transfer induces enhanced invasive properties (A) In vitro invasion assay of A549 cells co-cultured either with PMN or their conditioned supernatant produced in serum-free medium. (B) In vitro invasion assay of A549 cells co-cultured with conditioned supernatant depleted of EVs by ultra-centrifugation (UltraC). (C) In vitro invasion assay of A549 cells co-cultured with EVs isolated from PLB-985 cells. (D) In vitro invasion assay of antagomiR-223-3p (amiR-223-3p) transfected A549 cells co-cultured with SPN of PMN (E) In vitro invasion assay of A549 cells transiently transfected either with Ctrl siRNA (siCtrl) or FOXO1 siRNA (siFOXO). (A–E) Each dot corresponds to a biological replicate. * for P < 0.05, ** for P < 0.01, *** for P < 0.001.