FIG. 3.

Computational model of engineered muscle oxygen consumption. (A) Image of engineered myobundle after 2 weeks of differentiation in culture. (B) SolidWorks sketch of a representative myobundle area. (C) SolidWorks generated model of the myobundle volume with t representing the myobundle thickness. (D) Concentration profiles in myobundles with differing reaction values and thicknesses. (E) Oxygen concentration profile within myobundles of varying thicknesses during basal and maximal respiration. (F) The high effectiveness factors across all changes in myobundle thickness and respiration rates suggest that there are no oxygen diffusion limitations for the conditions used in this study.