Influence of fluid percussion injury (FPI) and FPI + epinephrine (EPI) on histopathology as a function of sex in juvenile pigs. (A) Male sham control (40 × ) showing CA1 (#1) and CA3 (#2) hippocampal regions. (B) Male sham control CA3 (100 × ). (C) Male FPI CA3 (100 × ). (D) Female FPI CA3 (100 × ). (E) FPI + EPI male CA3 (100 × ). (F) FPI + EPI female CA3 (100 × ). (G) Summary data for necrotic neurons in CA1 and CA3 before (sham), after FPI, and after FPI treated with EPI, n = 5. *p < 0.05 compared with corresponding sham control value, +p < 0.05 compared with corresponding FPI alone value, #p < 0.05 compared with corresponding female value.