Table 2.

Aberrant expression of DUBs associated with cancers.

DUB	Upregulated in Tumor	EMT and/or Metastasis	Signaling Effect	Reference
USP9X	Follicular lymphoma, Diffuse Large B-cell Lymphoma, breast adenocarcinoma, colon adenocarcinoma, small cell lung carcinoma	Lymph node	Mcl−1 (stabilization)	80
UCHL1	Gastric (in liver metastasis), NSCLC, breast (can also be downregulated), prostate (downregulated)	Liver, lung	Akt, Erk1/2, p38 MAPK, JNK	82-84,86
OTUB1	Colorectal, breast, prostate	Liver, pelvic, ovary, lymph node	TGFβ, MAPK, FOXM1	87-89