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Mdm2-A/B possesses intrinsic E3 ligase activity and can trans-ubiquitinate full length Mdm2 in vitro. (A) A diagram of Mdm2-A/B structure. (B) Mdm2-A/B autoubiquitination. Western blotting of polyubiquitin chain after in vitro ubiquitination reaction with indicated amounts of Mdm2-A/B. (C) Mdm2-A/B ubiquitinates full length Mdm2. (D) Trans-ubiquitination of full length enzyme-dead Mdm2L468A by Mdm2-A/B in vitro.
