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Mdm2-A potently ubiquitinates Mdm4, p53 and strongly stimulates p53 ubiquitination by Mdm2-Mdm4 in vitro. (A) Mdm2-A is more active than Mdm2 in ubiquitination of Mdm4. (B) Mdm2-A is more active than Mdm2 in p53 ubiquitination. (C) Mdm2-A-Mdm4 is more active heterodimer E3 ligase than Mdm2-Mdm4 in promoting p53 polyubiquitination in vitro.
