Table 2.
Univariable and Multivariable Analysis of Demographics and Geriatric Syndromes Associated with Beta-blocker Initiation after Resident Admission to Nursing Home after Acute Myocardial Infarction (N=15,720)
| Characteristic | Beta-blocker Initiation (n/n, %) |
Univariable Association (OR, 95% CI) |
Multivariable Association (OR, 95% CI)1 |
|---|---|---|---|
| All patients | 8,953 (57) | ||
| Age in years | |||
| 65 to <75 | 1,576/2,599 (61) | Reference | Reference |
| 75 to <85 | 3,291/5,720 (58) | 0.88 (0.80–0.97) | 0.89 (0.79–1.00) |
| 85 to <95 | 3,516/6,284 (56) | 0.83 (0.75–0.91) | 0.83 (0.73–0.94) |
| ≥95 | 570/1,117 (51) | 0.68 (0.59–0.78) | 0.65 (0.54–0.79) |
| Sex | |||
| Male | 2,649/4,580 (58) | Reference | Reference |
| Female | 6,304/11,140 (57) | 0.95 (0.89–1.02) | 0.97 (0.88–1.06) |
| Race | |||
| White, non-Hispanic | 7,232/12,829 (56) | Reference | Reference |
| Black, non-Hispanic | 1,158/1,914 (61) | 1.19 (1.08–1.31) | 1.13 (0.99–1.29) |
| Hispanic | 391/677 (58) | 1.06 (0.91–1.24) | 1.05 (0.86–1.28) |
| AI/AN/API | 172/300 (57) | 1.04 (0.83–1.31) | 0.98 (0.72–1.33) |
| Region | |||
| Northeast | 2,401/3,907 (62) | Reference | Reference |
| Midwest | 2,592/4,464 (58) | 0.87 (0.80–0.95) | 0.94 (0.83–1.07) |
| South | 2,902/5,451 (53) | 0.71 (0.66–0.78) | 0.81 (0.72–0.92) |
| West | 957/1,723 (56) | 0.78 (0.70–0.88) | 0.78 (0.67–0.92) |
| Caribbean | 101/175 (58) | 0.86 (0.63–1.16) | 0.98 (0.67–1.43) |
| CHESS score (health instability) | |||
| No instability | 5,093/8,836 (58) | Reference | Reference |
| Minimal | 2,562/4,524 (57) | 0.96 (0.89–1.03) | 0.94 (0.85–1.03) |
| Low | 1,066/1,941 (55) | 0.90 (0.81–0.99) | 0.85 (0.74–0.98) |
| Moderate to very high | 232/419 (55) | 0.91 (0.75–1.11) | 0.86 (0.67–1.12) |
| Cognition | |||
| Cognitively intact | 1,614/2,741 (59) | Reference | Reference |
| Mild dementia | 2,933/5,091 (58) | 0.95 (0.86–1.04) | 0.99 (0.88–1.12) |
| Moderate to severe dementia | 4,406/7,888 (56) | 0.88 (0.81–0.97) | 0.99 (0.87–1.13) |
| Activities of daily living status | |||
| Independent/limited assistance | 2,446/4,304 (57) | Reference | Reference |
| Extensive assistance | 4,145/7,196 (58) | 1.03 (0.96–1.11) | 0.95 (0.86–1.05) |
| Dependent/totally dependent | 2,362/4,220 (56) | 0.97 (0.89–1.05) | 0.84 (0.75–0.94) |
Abbreviations: OR, odds ratio; AI/AN/API, American Indian/Alaskan Native/Asian Pacific Islander; CHESS, Changes in Health, End-Stage Disease, Signs, and Symptoms Scale; ADLs, Activities of Daily Living.
1
Multivariable analyses also adjusted for a wide range of variables not shown here including demographics, clinical conditions, baseline medications, geriatric syndromes, AMI characteristics, and nursing home characteristics; see Supplementary Table 2 for complete list.