Table 2.
Baseline characteristics of hydroxychloroquine (HCQ) or immunosuppressive drug (ISD) initiators with SLE
| Database | Commercial Insurance Plans | Medicaid Insurance | ||
|---|---|---|---|---|
| Medication New Users | HCQ (n=2,451) | ISD (n=2,451) | HCQ (n=7,690) | ISD (n=7,690) |
| Age –mean ± SD | 45.7 ± 12.1 | 45.2 ± 12.1 | 39.2 ± 12.0 | 39.2 ± 12.4 |
| HPV-associated factors – N (%) | ||||
| Sexually active | 1920 (78.3) | 1943 (79.3) | 5560 (72.3) | 5569 (72.4) |
| Sexually transmitted disease | 150 (6.1) | 141 (5.8) | 729 (9.5) | 743 (9.7) |
| Alcoholism | 9 (0.4) | 10 (0.4) | 50 (0.7) | 29 (0.6) |
| Substance abuse | 20 (0.8) | 23 (0.9) | 163 (2.1) | 162 (2.1) |
| Smoking | 247 (10.1) | 265 (10.8) | 976 (12.7) | 976 (12.7) |
| Oral contraceptives | 225 (9.2) | 232 (9.5) | 566 (7.4) | 588 (7.7) |
| Non-oral contraceptives | 41 (1.7) | 39 (1.6) | 287 (3.7) | 279 (3.6) |
| Receipt of HPV vaccine | 15 (0.6) | 15 (0.6) | 33 (0.4) | 32 (0.4) |
| Abnormal Papanicolaou test | 130 (5.3) | 142 (5.8) | 409 (5.3) | 420 (5.5) |
| Comorbidities – N (%) | ||||
| Chronic kidney disease | 270 (11.0) | 253 (10.3) | 1156 (15.0) | 1186 (15.4) |
| Liver disease | 169 (6.9) | 166 (6.8) | 563 (7.3) | 542 (7.1) |
| Diabetes mellitus | 270 (11.0) | 252 (10.3) | 1106 (14.4) | 1159 (15.1) |
| Mean comorbidity score ± SD* | 0.8 ± 1.6 | 0.8 ± 1.5 | 1.1 ± 1.8 | 1.1 ± 1.7 |
| Medications | ||||
| Mean number of prescriptions ± SD | 12.2 ± 7.4 | 12.2 ± 7.0 | 16.4 ± 9.2 | 16.5 ± 8.6 |
| Corticosteroid use – N (%) | 1006 (41.0) | 1004 (41.0) | 4252 (55.3) | 4171 (54.2) |
| Preventive Care – N (%) | ||||
| Mammogram | 890 (36.3) | 858 (35.0) | 1367 (17.8) | 1385 (18.0) |
| Papanicolaou test | 1065 (43.5) | 1058 (43.2) | 2285 (29.7) | 2310 (30.0) |
| HPV DNA ordered | 218 (8.9) | 215 (8.8) | 346 (4.5) | 356 (4.5) |
| Colonoscopy | 243 (9.9) | 234 (9.6) | 453 (5.9) | 456 (5.9) |
| Healthcare utilization- mean ± SD | ||||
| Outpatient visits | 12.5 ± 8.3 | 12.7 ± 8.9 | 10.8 ± 9.3 | 10.9 ± 8.6 |
| Hospitalizations | 0.6 ± 2.5 | 0.6 ± 1.9 | 0.7 ± 1.4 | 0.7 ± 1.4 |
| Emergency Department visits | 0.7 ± 3.2 | 0.8 ± 3.4 | 2.2 ± 3.9 | 2.1 ± 3.8 |
*
The range of the comorbidity score is −2 to 26.