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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: J Pathol. 2017 Mar 15;242(1):52–61. doi: 10.1002/path.4878

Figure 2. Cramp−/− and wild type macrophages differ in intracellular growth of bacteria and IL12p40 production upon M. tuberculosis infection leading to accelerated progression of TB disease in Cramp−/− mice.

Figure 2

BMDMs from wild type and Cramp−/− mice were infected in triplicate with M. tuberculosis. (A) Macrophages were lysed and bacteria plated for intracellular growth at different time points. (B) 1 million BMDM were infected with CDC1551 (MOI=2) and levels of IL12p40 was measured at 24 hrs by ELISA. (C) Time to death of wild type and Cramp −/− mice after aerosol infection. For A and B, ★★ and ★★★ denotes p < 0.01 and <0.001 respectively. For C, p <0.0001 from Fisher’s exact test.