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. Author manuscript; available in PMC: 2018 May 1.
Published in final edited form as: J Pathol. 2017 Mar 15;242(1):52–61. doi: 10.1002/path.4878

Figure 5. Cathelicidin expression is regulated by cAMP accumulation in macrophages.

Figure 5

(A) RT-PCR of macrophages treated with dibutyryl-cAMP. (B) RT-PCR of macrophages 24 h after infection with different recombinant strains of bacteria.JHU-0386 is CDC1551 containing a transposon insertion in the adenylate cyclase gene Rv0386 while JHU-0386-Comp is JHU-0386 complemented with a wild type copy of Rv0386. (C) Scheme of cAMP dependent cathelicidin expression inhibition and consequent reductions in immune control pathways. Data shown are representative of three independent experiments. ★ and ★★ denotes p < 0.05 and <0.01 respectively.