Figure 1.

Overview of the methodology employed. We first generated an integration scaffold of islet protein complexes in healthy tissue (A) and defined a subset of complexes with coordinated expression in islets (B) that were further benchmarked (C,D). We then identified the subset of islet complexes with potential dysregulation in the T2D state by functional convergence of 13 islet diabetic phenotype gene sets (E), followed by functional annotation and validation (F–H). For comparison, direct convergence of the islet diabetic phenotype gene sets was evaluated (E).