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. 2017 Apr 20;8:43. doi: 10.3389/fgene.2017.00043

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Copyright © 2017 Pedersen, Gudmundsdottir and Brunak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Breakdown of significantly enriched complex-trait combinations. (A) The enrichment of GWAS signals for each of the 30 significant complex-trait combinations when including all genes, excluding input genes, and excluding genes with genome-wide significant association in the given GWAS (see Section Methods for details). The genes in each complex-trait combination are colored based on P-value (i.e., minimum P-value for the SNPs mapping to the respective gene) partitioned into factor-10 groups; (B) actual count and (C) percentage distribution of gene P-values within a complex in the GWAS for the given glycemic trait. (D) Example of complexes.