Table 2.
Plausible novel T2D genes prioritized from the complexes with potential T2D dysregulation.
| Gene symbol | Gene name | # Islet diabetic phenotype gene sets | # Islet biology gene sets | Minimum P-value for associated SNPs | Corresponding GWAS trait |
|---|---|---|---|---|---|
| MAP2K4 | Mitogen-activated protein kinase kinase 4 | 0 | 1 | 7.83 × 10−6 (rs929441) | AUCIns/AUCGluc |
| PDLIM5 | PDZ and LIM domain 5 | 0 | 1 | 9.87 × 10−5 (rs17021900) | Fasting glucose |
| PPP2R5E | Protein phosphatase 2, regulatory subunit B, epsilon isoform | 0 | 1 | 7.05 × 10−5 (rs10151995) | Fasting glucose |
| SNX13 | Sorting nexin 13 | 0 | 1 | 4.02 × 10−6 (rs2723517) | HbA1c |
| GNAS | GNAS complex locus | 0 | 1 | 4.73 × 10−5 (rs6026565) | Fasting glucose, Manning |
| FRS2 | Fibroblast growth factor receptor substrate 2 | 0 | 1 | 9.76 × 10−6 (rs12425398) | Fasting glucose, Manning |
Genes are prioritized if they, besides being part of a protein complex showing potential T2D dysregulation, are part of at least one of the four islet biology gene sets and harbor at least one SNP with P < 1 × 10−4 in one or more of the 19 GWAS described in Supplementary Table 6. Only the best SNP P-value and corresponding GWAS trait are shown. To focus on novel T2D genes, genes in any of the 13 islet diabetic phenotype gene sets are excluded.