Table 3.

Effect of MCV-ACPA and other variables on bone mineral density (mg/cm²) at lumbar spine, hip, and MCP joints

	Lumbar spine (n = 523)		Femoral neck (n = 537)		Total hip (n = 537)		MCP 2nd–5th (n = 372)
	β coef. (95% CI)	p	β coef. (95% CI)	p	β coef. (95% CI)	p	β coef. (95% CI)	p
MCV-ACPA level
Negative	Ref	–	Ref	–	Ref	–	Ref
Low	−27 (−58; 4)	0.086	−17 (−40; 7)	0.160	−30 (−54; −5)	0.018	7 (−4; 18)	0.218
High	−30 (−61; 1)	0.059	−9 (−33; 14)	0.447	−2 (−27; 22)	0.865	3 (−9; 13)	0.712
Female	−30 (−65; 6)	0.099	−23 (−50; 4)	0.092	−48 (−77; −20)	0.001	−24 (−35; −13)	<0.001
Age (years)
<45	Ref	–	Ref	–	Ref	–	Ref	–
45–65	−45 (−77; −12)	0.007	−55 (−80; −30)	<0.001	−31 (−57; −5)	0.021	−5 (−15; 5)	0.331
>65	−68 (−106; −30)	<0.001	−134 (−163; −105)	<0.001	−105 (−135; −75)	<0.001	−40 (−51; −28)	<0.001
BMI (kg/m2)	5 (3; 8)	<0.001	9 (7; 11)	<0.001	11 (9; 13)	<0.001	2 (2; 3)	<0.001
Menopause
No	Ref	–	Ref	–	Ref	–	Ref	–
Yes	−75 (−107; −43)	<0.001	−53 (−78; −28)	<0.001	−71 (−97; −45)	<0.001	−19 (−29; −9)	<0.001
Not available	−72 (−146; 1)	0.054	−31 (−86; 24)	0.268	−29 (−86; 29)	0.329	−22 (−41; −3)	0.023
2010 ACR/EULAR RA criteria	N.I		N.I		N.I		−9 (−19; 0)	0.055

coef coefficient, CI confidence interval, MCV-ACPA anti-mutated citrullinated vimentin antibodies, ref. reference, BMI body mass index, RA rheumatoid arthritis, N.I. not included, MCP metacarpophalangeal joints