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. 2017 Mar 27;37(5):775–783. doi: 10.1007/s00296-017-3711-8

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Maintenance (a) and de novo DNMTs (b) methylate DNA. DNMT1 binds methyl groups to the hemimethylated DNA during replication, whereas DNMT3A and DNMT3B can add methyl groups to CpG dinucleotides of unmethylated DNA. From Luczak and Jagodziński [23]