Table 4.

Diagnostic accuracy of WB and SPECT, 2D SPECT/CT, and 3D SPECT/CT for two independent readers and inter-reader variability

	Reader 1				Reader 2				Inter-reader variability*
	Sens (%)	Spec (%)	PPV (%)	NPV (%)	Sens (%)	Spec (%)	PPV (%)	NPV (%)
Renal, esophageal and hepatic cancers (n = 43)
WB and SPECT	20	74	29	64	34	85	55	71	0.66
2D SPECT–CT	78	98	95	89	90	99	97	95	0.88
3D SPECT–CT	79	99	97	90	90	99	97	95	0.89
The other cancers (n = 275)
WB and SPECT	85	78	75	87	87	84	81	91	0.82
2D SPECT–CT	93	99	98	94	96	99	99	97	0.91
3D SPECT–CT	93	98	97	95	96	99	99	97	0.91
Total (n = 318)
WB and SPECT	78	77	72	83	82	84	79	86	0.72
2D SPECT–CT	91	99	98	94	95	99	99	96	0.90
3D SPECT–CT	91	98	97	94	95	99	98	96	0.89

Sens sensitivity, Spec specificity, PPV positive predictive value, NPV negative predictive value

^* Weighted kappa value based on the four-point scale