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. 2017 Apr 20;10:105. doi: 10.3389/fnmol.2017.00105

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Copyright © 2017 Yang, Zhou, Qian, Wang, He, Tang, Yin and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-dipsogenic effects were related to increased adropin under hypoxia in rats. (A) The experimental design to study the mechanism of central anti-dipsogenic effects (Figures 1, 2). (B) Adropin protein in circumventricular organs (CVOs) nuclei was down-regulated 25 h after injection of 10 μl adropin antibody into the third ventricle after overnight water deprivation-induced drinking in rats. (C) Relative protein expression was calculated (n = 6 for each group, *P < 0.05). (D) The expression of serum adropin was enhanced under hypoxia (3700 m and 6000 m) at 1, 2 and 3 days after overnight water deprivation-induced drinking in rats (n = 8 for each group; *P < 0.05 vs. normoxia group; ^#P < 0.05 vs. 3700 m hypoxia group). (E) Hypoxia induced anti-dipsogenic effects was alleviated after administration of 10 μl rat source special adropin antibody under hypoxia (3700 m) after overnight water deprivation-induced drinking in rats (IgG as a control, n = 8 for each group; *P < 0.05 vs. normoxia group; ^#P < 0.05 vs. 3700 m hypoxia group).