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. 2017 Apr 20;10:105. doi: 10.3389/fnmol.2017.00105

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Copyright © 2017 Yang, Zhou, Qian, Wang, He, Tang, Yin and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Suppression of c-Fos under hypoxia was relieved when adropin was neutralized in CVO nuclei of rats. (A) The reduction of c-Fos positive cells (visualized as brown staining) in Subfornical organ (SFO) and Median preoptic nucleus (MnPO) regions under hypoxia (3700 m) was recovered 25 h after administration of 10 μl adropin antibody in the third ventricle after overnight water deprivation-induced drinking in rats, Scale bar, SFO:200 μm, MnPO, OVLT: 100 μm. (B) Quantification of c-Fos positive cells (three rats for each group; *P < 0.05 vs. normoxia group, ^#P < 0.05 vs. 3700 m hypoxia group).