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. 2017 Apr 20;8:61. doi: 10.3389/fpsyt.2017.00061

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Copyright © 2017 Jaehne, Ameti, Paiva and van den Buuse.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Acute methamphetamine (Meth) induced hyperactivity following chronic Meth exposure. A low acute challenge dose of Meth (1 mg/kg) induced hyperactivity in mice previously pretreated with Meth. There was no genotype effect at this dose. A high acute challenge dose of Meth (3 mg/kg) induced hyperactivity to a significantly greater extent in Meth pretreated compared to saline pretreated mice. This dose also induced hyperactivity to a significantly greater extent in 5-HT_1A knockout (KO) mice compared to wild-type (WT) mice. Results are shown for males and females combined.