Figure 2.

(A) Average prepulse inhibition (PPI) across all four PP intensities was significantly higher in 5-HT_1A knockout (KO) females compared to wild-type (WT) females. There was no difference in PPI between any groups in male mice. (B) Average startle responses across all four startle blocks were significantly lower in female 5-HT_1A KO mice compared to WT, and higher in female Meth pretreated compared to saline pretreated mice. There was no difference in startle between any groups in male mice. ** signifies genotype effect p < 0.01, *** signifies p < 0.001.