Figure 2.

Metformin does not alter the development of SS hypertension. (A) Experimental protocol for BP recording. Continuous BP acquisition via catheters was performed in conscious Dahl SS rats placed on an 8% NaCl diet and subjected to an intravenous infusion of metformin (n = 9) or vehicle (n = 6). (B) Representative systolic (black) and diastolic (red) blood pressure recordings from a vehicle-treated animal. Data were averaged in 1 min intervals. (C) Mean arterial blood pressure (MAP) in the vehicle- and metformin-treated groups. (D) Metformin does not affect MAP circadian dipping increase during development of hypertension. (E) Representative heart rate trace acquired from a vehicle-treated animal. (F) Lack of effect of metformin on heart rate in experimental animals. ^*,^#p < 0.05 vs. 0.4% NaCl; ^§,$p < 0.05 vs. 8 days on 8% NaCl.