Table 1.

List of major absorption, distribution, metabolism, and excretion proteins for which surrogate peptides were selected.

Phase I Enzymes

ADH1A, ADH1B*, ADH1C*, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A1*, ALDH1A2*, ALDH1A3*, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH4A1, ALDH5A1, ALDH6A1, ALDH7A1, ALDH8A1, ALDH9A1, AOX1*, CBR1, CBR3, CES1*, CES2, CYB5R3, CYP1A1*, CYP1A2*, CYP1B1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP19A1, CYP20A1, CYP20A1, CYP21A2, CYP24A1, CYP26A1, CYP26C1, CYP27A1, CYP27B1, CYP2A13, CYP2A6*, CYP2A7, CYP2B6, CYP2C8*, CYP2C9*, CYP2C18*, CYP2C19, CYP2D6*, CYP2D7P1, CYP2E1*, CYP2F1, CYP2J2*, CYP2R1, CYP2S1, CYP3A4*, CYP3A5*, CYP3A7, CYP3A43*, CYP4A11, CYP4B1, CYP4F11, CYP4F12, CYP4F2, CYP4F3, CYP4F8, CYP4Z1, CYP7A1, CYP7B1, CYP8B1, CYP39A1, CYP46A1, CYP51A1, DDO, DHRS1, DHRS2, DHRS3, DHRS4, DHRS4L1, DHRS4L2, DHRS7, DHRS7B, DHRS7C, DHRS9, DHRS12, DHRS13, DHRSX, DPEP1, DPYD*, EPHX1*, EPHX2*, FMO1*, FMO2*, FMO3*, FMO4, FMO5, FMO6P, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, HAGH, HSD11B1, HSD17B11, HSD17B14, LOC728667, LOC731356, LOC731931, METAP1, NOS1, NOS2A, NOS3, PDE3A, PDE3B, PLGLB1, PON1, PON2, PON3, SULF1, XDH

Phase II Enzymes

CHST1, CHST2, CHST3, CHST4, CHST5, CHST6, CHST7, CHST8, CHST9, CHST10, CHST11, CHST12, CHST13, GSTA1*, GSTA2, GSTA3*, GSTA4, GSTA5*, GSTCD, GSTK1, GSTM1*, GSTM2*, GSTM3*, GSTM4*, GSTM5, GSTO1, GSTO2, GSTP1*, GSTT1*, GSTT2, GSTZ1, HNMT, MGST1, MGST2, MGST3, NAT1*, NAT2*, NNMT, PNMT, SULT1A1*, SULT1A2*, SULT1A3, SULT1B1, SULT1C1/C2*, SULT1E1, SULT2A1*, SULT2B1*, SULT4A1, TPMT, UGT1A1*, UGT1A3*, UGT1A4*, UGT1A5*, UGT1A6, UGT1A7, UGT1A8*, UGT1A9*, UGT1A10*, UGT2A1*, UGT2B4*, UGT2B7*, UGT2B10, UGT2B11, UGT2B15*, UGT2B17, UGT2B28, UGT8*

Transporters

ABCA1 (CERP), ABCA4, ABCB1 (P‐gp, MDR1)*, ABCB2 (TAP1), ABCB3 (TAP2), ABCB4 (MDR3), ABCB5, ABCB6 (PRP, UMAT), ABCB7, ABCB8 (MABC1), ABCB11 (BSEP), ABCC1 (MRP1), ABCC2 (MRP2)*, ABCC3 (MRP3), ABCC4 (MRP4)*, ABCC5 (MRP5), ABCC6 (MRP6), ABCC8 (SUR1), ABCC9 (SUR2), ABCC10 (MRP7), ABCC11 (MRP8), ABCC12 (MRP9), ABCC13, ABCG1 (WHT1), ABCG2 (BCRP)*, SLC2A4 (GLUT4), SLC2A5 (GLUT5), SLC5A6 (SMVT), SLC6A6, SLC7A5 (LAT1), SLC7A7, SLC7A8 (LAT2), SLC10A1 (NTCP), SLC10A2 (NTCP2), SLC13A1 (NAS1), SLC13A2 (NADC1), SLC13A3 (NADC3), SLC15A1 (PEPT1), SLC15A2 (PEPT2), SLC16A1 (MCT1), SLC19A1 (FLOT1), SLC22A1 (OCT1)*, SLC22A2 (OCT2)*, SLC22A3 (OCT3)*, SLC22A4 (OCTN1)*, SLC22A5 (OCTN2)*, SLC22A6 (OAT1)*, SLC22A7 (OAT2), SLC22A8 (OAT3)*, SLC22A9 (OAT7)*,SLC22A10 (OAT5), SLC22A11 (OAT4), SLC22A12 (URAT1)*, SLC22A13 (OAT10), SLC22A14 (OCTL2), SLC22A15 (FLIPT1), SLC22A16 (OCT6), SLC22A17 (BOIT), SLC22A18 (BWR1A), SLC22A18AS (BWR1B), SLC27A1 (FATP1), SLC28A1 (CNT1)*, SLC28A2 (CNT2)*, SLC28A3 (CNT3)*, SLC29A1 (ENT1), SLC29A2 (ENT2), SLC47A1 (MATE1), SLC47A2 (MATE2K), SLCO1A2 (OATP1A2)*, SLCO1B1 (OATP1B1)*, SLCO1B3 (OATP1B3)*, SLCO1C1 (OATP1C1), SLCO2A1 (OATP2A1), SLCO2B1 (OATP2B1), SLCO3A1 (OATP3A1), SLCO4A1 (OATP4A1), SLCO4C1 (OATP4C1), SLCO5A1 (OATP5A1), SLCO6A1 (OATP6A1)

Nuclear Receptors AHR, CAR, FXR, GCR, HNF4α, PGR, PXR

Proteins shown in bold were detected in different human tissues and the asterisk (*) indicates availability of surrogate peptide with change in amino acid due to single nucleotide polymorphism. UniProt IDs provided in Supplementary Table S2.