Figure 4.

Simulated and observed plasma concentration‐time profile of 5 mg rosuvastatin when administered in the presence or absence of a single dose of (a) oral and (b) i.v. rifampin 600 mg. Ten trials were simulated with 10 healthy subjects/trial (50% women; age, 19–55 years). Red curves indicate the presence of rifampin and green curves indicate the absence of rifampin. Curves in black represent the simulated mean profiles of all simulation trials. Circles and triangles represent observed data in the absence and presence of rifampin from Prueksaritanont et al.29 in 2014. Inset panels show simulated vs. observed area under the curve (AUC) and maximum concentration (C_max) ratios of rosuvastatin in the presence of rifampin. Error bars in the insets represent 90% confidence intervals.