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. Author manuscript; available in PMC: 2017 Apr 20.
Published in final edited form as: Biol Psychiatry. 2015 Oct 21;80(4):284–292. doi: 10.1016/j.biopsych.2015.10.009

Fig. 3. Q-Q and fold enrichment plots showing schizophrenia association enrichment of brain genes with negative Neanderthal selective sweep (NSS) score.

Fig. 3

Shown are A) the quantile- quantile (Q-Q) and B) the fold enrichment plots for: SNPs annotated to generic genes (Any); SNPs annotated to genes associated with the brain, as established by an NCBI site search (Brain); SNPs annotated to genes associated with the brain, defined by Kang et al. (34) (Neuro); SNPs with negative NSS score and annotated to genes associated with the brain, as established by an NCBI site search (NSSBrain); or to genes defined by Kang et al. (34) (NSSNeuro); and all SNPs (All SNPs). The NSS Brain category is enriched (deflected left) compared to the other categories, i.e. presents a higher incidence of associations (lower p-values) with schizophrenia (SCZ). This is confirmed by the Binomial Proportion Test (BPT) comparing Brain and NSS Brain groups (p = 5.5×10−3).