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. Author manuscript; available in PMC: 2017 Apr 20.
Published in final edited form as: Biol Psychiatry. 2015 Oct 21;80(4):284–292. doi: 10.1016/j.biopsych.2015.10.009

Fig. 4. Replication plot for schizophrenia with and without conditioning on Neanderthal selective sweep score < 0.

Fig. 4

SNPs with negative Neanderthal selective sweep score (NSS) score tend to replicate better than baseline SNPs across the 52 schizophrenia (SCZ) meta-analysis sub studies. For example, at a −log(p)-value level of 4 the cumulative replication rate improves from 60% to about 80% when restricting the choice to SNPs with negative NSS score. A negative NSS score seems therefore to be a viable aid to identify non-spurious schizophrenia associations.