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Influenza infection induces lasting endoplasmic reticulum stress in the lung parenchyma. C57BL/6 mice were infected with influenza A/PR/8/34 or control PBS vehicle for the indicated time points. A: Immunofluorescence for ATF6 (green = nuclei, blue = ATF6, representative images). B: Western blot analysis of CHOP expression. n = 4–5 (B). Original magnification, ×200. ATF6, activating transcription factor 6; CHOP, C/EBP homologous protein; FLU, influenza; PBS, phosphate-buffered saline.
