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. 2017 Apr;187(4):724–739. doi: 10.1016/j.ajpath.2016.12.011

Figure 7.

Figure 7

Effect of apelin (Ap)-13 on myo-inositol oxygenase (MIOX) expression in HK-2 cells subjected to high-glucose (HG) ambience. Treatment of HK-2 cells with and without apellin-13 (A), an inhibitor of histone hyperacetylation, considerably reduces the MIOX expression under high-glucose ambience, as assessed by immunofluoresence microscopy (B and C) and immunoblot analyses (D and E). Data are expressed as means ± SEM. n = 4 independent experiments (E). ∗P < 0.05 versus the respective control. Scale bars = 40 μm (A–C). LG, low-glucose.