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. 2017 May;24(5):210–215. doi: 10.1101/lm.043646.116

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© 2017 Richlitzki et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — EPAC and PKA act via a similar pathway downstream from rutabaga. STM performance is not sensitive to genetic interactions between the cAMP intermediaries PKA and epac with each, other or with the rutabaga adenylyl cyclase. (A) Knockdown of DC0, Drosophilás most abundant catalytic PKA subunit reduced PKA activity of brain homogenate. (B) Pan-neuronal DC0 knockdown diminishes STM performance. (C) Shock reactivity and odor acuity are not affected by DC0 knockdown. (D) Induced knockdown of DC0 at the adult stage by means of the TARGET system diminishes STM performance. (E) STM is not sensitive to interactions between the cAMP intermediaries PKA and epac. (F) STM is not sensitive to interactions between the rutabaga adenylyl cyclase and PKA or EPAC. All data represent means ± SEM. N = 6–8. Statistical differences at the level of P ≤ 0.05 are denoted by different letters.