Table 3.
Univariate analysis of prognostic factors (except for SVZ-dosimetric data) for time-to-progression (TTP) and overall survival (OS) in patients with newly diagnosed glioblastoma
| Prognostic factors | Median TTP (months) |
p value | Median OS (months) |
p value |
|---|---|---|---|---|
| Age | ||||
| < 60 years | 5.2 | 0.651 | 24.7 | 0.914 |
| ≥ 60 years | 6.4 | 14.4 | ||
| Gender | ||||
| Male | 4.8 | 0.406 | 20.5 | 0.603 |
| Female | 9.1 | 26.2 | ||
| ECOG performans status | ||||
| 0–1 | 5.3 | 0.366 | 24.7 | 0.465 |
| 2–4 | 6.7 | 14.6 | ||
| Multilobar lesion | ||||
| No | 5.6 | 0.826 | 20.7 | 0.896 |
| Yes | 6.4 | 22.7 | ||
| Tumor SVZ contact | ||||
| Yes | 4.6 | 0.002 | 18.7 | 0.014 |
| No | 12.9 | 41.7 | ||
| MGMT status | ||||
| Methylated | 5.3 | 0.245 | 24.7 | 0.281 |
| Unmethylated | 6.4 | 20.5 | ||
| Extent of resection | ||||
| GTR/NTR | 5.6 | 0.669 | 25.1 | 0.598 |
| STR | 6.4 | 18.7 | ||
Abbreviations: MGMT O6-methylguanine-DNA-methyltransferase, GTR Gross Total Resection, NTR Near Total Resection, STR SubTotal Resection