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. 2017 Apr;187(4):700–712. doi: 10.1016/j.ajpath.2016.12.004

Figure 8.

Figure 8

A: Cellular proliferation was assessed by quantification of the Ki-67–positive cells (expressed as Ki-67–positive cells in percentage of total cells nuclei per field) in the sham, PE, and PE + SU rats. B: Representative images of immunohistochemistry for Ki-67 stain (positive cells indicated by arrows) on rat lung sections from animals in the sham, PE, and PE + SU groups at 6 weeks. C: Verhoeff–van Gieson staining reveals medial hypertrophy and lumen obliteration in small pulmonary arterioles in PE + SU rats. Histological sections of Masson's trichrome staining [left ventricular (LV; (D) and right ventricular (RV; E)] on sham, PE, PE + SU, and SU groups at 6 weeks after chronic thromboembolic pulmonary hypertension. Masson's trichrome stain showing RV fibrosis (blue color indicates collagen accumulation) in PE group but more extensive in the PE + SU group. No LV fibrosis is observed. n = 6 per group (A). ∗P < 0.05 for sham and PE versus PE + SU group. Scale bars: 50 μm (B, D, and E); 200 μm (C). Original magnification, ×200 (B–E).