Table 2.
Distribution of FcγRIIA-131Arg/His, FcγRIIIA-176F/V and FcγRIIIB-NA1/NA2 genotypes within the study groups
| N (%) with genotype in groupa | HWE, P-value (SMA + non-SMA) c |
|||
|---|---|---|---|---|
| Genotypes | SMA (Hb < 6.0 g/dL) (n = 114) |
Non-SMA (Hb ≥ 6.0 g/dL) (n = 160) |
P-value b | |
| FcγRIIA-131Arg/His | ||||
| Arg/Arg, n (%) | 30 (26.3) | 39 (24.3) | ||
| Arg/His n (%) | 59 (51.8) | 71 (44.4) | 0.226b | 0.402b |
| His/His, n (%) | 25 (21.9) | 50 (31.3) | ||
| X(His) = 0.48 | ||||
| FcγRIIIA-176 F/V | ||||
| FF, n (%) | 61 (53.5) | 77 (48.1) | ||
| FV, n (%) | 45 (39.5) | 60 (37.5) | 0.162b | 0.113b |
| VV, n (%) | 8 (7.0) | 23 (14.4) | ||
| X(V) = 0.30 | ||||
| FcγRIIIB-NA1/NA2 | ||||
| NA1/NA1 | 6 (5.3) | 8 (5.0) | ||
| NA1/NA2 | 73 (64.0) | 94 (58.8) | 0.632b | <0.001 b |
| NA2/NA2 | 35 (30.7) | 58 (36.2) | ||
| X(NA1) = 0.36 | ||||
aData are presented as n (%) of children. Children with parasitemia were categorized on the basis of presence or absence of severe malarial anemia SMA based (defined as Hb < 6.0 g/dL, with any density parasitemia). bStatistical significance determined by χ2 analysis. X; the overall minor allele frequency in the study population. c HWE Hardy-Weinberg Equilibrium
Values in bold are significant p-values at a cut-off of p≤0.05