Table 3.
Association between FcγRIIA-131Arg/His, FcγRIIIA-176F/V, FcγRIIIB-NA1/NA2 and severe malarial anemia (SMA, Hb < 6.0 g/dL)
| FcγR genotype models | SMA (Hb < 6.0 g/dL) | ||||
|---|---|---|---|---|---|
| SMA | Non-SMA | OR | 95% CI | P-value | |
| FcγRIIA-131Arg/His | |||||
| Dominant, (His/His, n = 75) | 25 | 50 | 0.59 | 0.33–1.05 | 0.077 |
| Additive, (Arg/His, n = 130) | 59 | 71 | 1.52 | 0.72–2.93 | 0.298 |
| Recessive, (Arg/Arg, n = 69) | 30 | 39 | 0.98 | 0.56–1.75 | 0.963 |
| FcγRIIIA-176 F/V | |||||
| Dominant, (F/F, n = 138) | 61 | 77 | 1.27 | 0.79–2.10 | 0.343 |
| Additive, (F/V, n = 105) | 45 | 60 | 0.77 | 0.63–1.83 | 0.796 |
| Recessive, (V/V, n = 31) | 8 | 23 | 0.43 | 0.18–1.02 | 0.056 |
| FcγRIIIB-NA1/NA2 | |||||
| Dominant, (NA2/NA2, n = 93) | 35 | 58 | 0.76 | 0.44–1.28 | 0.786 |
| Additive, (NA1/NA2, n = 167) | 73 | 94 | 1.34 | 0.78–2.30 | 0.288 |
| Recessive, (NA1/NA1, n = 14) | 6 | 8 | 1.20 | 0.36–3.94 | 0.767 |
Children with acute malaria (n = 274) were grouped based on SMA (defined as Hb < 6.0 g/dL, with any density parasitemia) [25]. Odds ratios (OR) and 95% confidence intervals (CI) were determined using bivariate logistic regression controlling for age, gender, co-infections (HIV-1 and bacteremia) sickle cell trait (HbAS) and G6PD deficiency. The reference groups in the logistic regression analysis were the absence of the respective models for each genotype. n = the number of participants with the respective genotype. P-values were considered significant at P ≤ 0.05
Values in bold are significant p-values at a cut-off of p≤0.05