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. 2017 Apr 20;7:46514. doi: 10.1038/srep46514

Figure 1. Transient IFNβ expression is accompanied by up-regulation of interferon-stimulated genes in HIVgp120tg mouse brains.

Figure 1

Total brain RNA was extracted from age-matched HIVgp120tg and wild type control, male animals and qRT-PCR analysis was used to assess differential regulation of the indicated genes between the age-groups: (a) IFNβ; (b) IFNα; (c) MX1; (d) CXCL11; (e) CXCL10; (f) CCL2. GAPDH was used as internal control, and representative results are shown as fold-change (FC) differences compared to the WT control within the age group. Data are shown as mean ± s.e.m. (***P ≤ 0.001, **P ≤ 0.01 by ANOVA with Fisher’s PLSD post hoc test). n = 3–4 animals per group/genotype.