Table 1. Clinical, biological and polysomnographical characteristics of RLS patients, healthy controls, and RLS patients sorted according to the MEIS1 SNP rs2300478 genotype (GG or TT).
| Control | RLS | p | pa | RLS GG | RLS TT | p | |
|---|---|---|---|---|---|---|---|
| N | 38 | 64 | NA | NA | 20 | 44 | NA |
| Age | 45.0 ± 9.5 | 61.5 ± 8.8 | 5.10−7*** | NA | 67.0 ± 8.0 | 60.0 ± 6.1 | 0.57 |
| Men, n (%) | 9 (23.7%) | 30 (46.9%) | 0.03* | NA | 10 (50%) | 20 (45.5%) | 0.95 |
| BMI | 26.9 ± 5.2 | 25.9 ± 3.1 | 0.38 | 0.792 | 25.4 ± 2.5 | 26.8 ± 3.2 | 0.22 |
| Ferritin | 68.5 ± 42.5 | 83.0 ± 50.0 | 0.12 | 0.911 | 84.5 ± 52.0 | 80.0 ± 48.5 | 0.76 |
| Age onset | NA | 45.0 ± 12.5 | NA | NA | 38.0 ± 13.0 | 50.0 ± 8.0 | 0.44 |
| RLS sev. | NA | 25.0 ± 4.0 | NA | NA | 26.5 ± 5.5 | 24.0 ± 5.0 | 0.28 |
| TST (min) | 382 ± 41 | 346 ± 48 | 0.0007*** | 0.0046## | 350 ± 67 | 346 ± 47 | 0.62 |
| SE (%) | 85 ± 8 | 74 ± 9 | 0.0001*** | 0.0748 | 70 ± 12 | 75 ± 9 | 0.79 |
| WASO | 36 ± 18 | 88 ± 31 | 0.0003*** | 0.0909 | 83 ± 19 | 89 ± 45 | 0.42 |
| SL | 16 ± 12 | 19 ± 11 | 0.45 | 0.623 | 21 ± 13 | 19 ± 10 | 0.17 |
| N1 (%) | 6.1 ± 3.1 | 7.8 ± 2.7 | 0.026* | 0.4104 | 7.5 ± 2.6 | 8.8 ± 6.3 | 0.44 |
| N2 (%) | 54.0 ± 3.5 | 49.8 ± 5.0 | 0.034* | 0.00265## | 47.9 ± 6.7 | 50.2 ± 8.4 | 0.81 |
| N3 (%) | 21.0 ± 3.2 | 21.1 ± 6.4 | 0.98 | 0.16679 | 20.9 ± 7.3 | 22.2 ± 8.4 | 0.45 |
| REM (%) | 16.7 ± 4.0 | 19.0 ± 4.3 | 0.35 | 0.0572 | 19.4 ± 4.7 | 18.9 ± 6.5 | 0.41 |
| iPLMNREM | 1.1 ± 1.1 | 38.3 ± 20.6 | 1.10−4*** | 0.00042### | 62.6 ± 36.2 | 29.9 ± 15.8 | 4.10−9*** |
| iPLMREM | 0 ± 0 | 4.1 ± 4.1 | 8.10−9*** | 0.08718 | 12.4 ± 11.6 | 2.2 ± 2.2 | 0.32 |
| AHI | 1.9 ± 1.4 | 4.4 ± 4.1 | 0.19 | 0.7298 | 5.2 ± 5.0 | 4.4 ± 3.9 | 0.49 |
| Min SaO2 | 91.5 ± 2.5 | 88.0 ± 4.0 | 0.16 | 0.8966 | 87.5 ± 3.5 | 88.0 ± 4.0 | 0.71 |
| Mean SaO2 | 95.5 ± 1.5 | 95.0 ± 1.0 | 0.41 | 0.173 | 94.0 ± 2.0 | 95.0 ± 1.0 | 0.64 |
| tSA O2 <90% | 0 ± 0 | 0.11 ± 0.11 | 0.19 | 0.3758 | 0.17 ± 0.17 | 0.04 ± 0.04 | 0.38 |
BMI = body mass index; Ferritin = ferritin blood levels, RLS sev. = RLS severity index; TST = Total Sleep Time in minutes; SE = Sleep Efficiency; WASO = Wake After Sleep Onset; SL = Sleep Latency; N1 (%) = percentage of cumulated N1 stages duration over TST; N2 (%) = percentage of cumulated N2 stages duration over TST; N3 (%) = percentage of cumulated N3 stages duration over TST and REM (%) = percentage of cumulated REM stages duration over TST; iPLMNREM = PLM index during NREM sleep; iPLMREM = PLM index during REM sleep; AHI = apnea/hypopnea per hour of sleep index; Min SaO2 = minimal oxygen saturation; Mean SaO2 = average of oxygen saturation; tSA O2 <90% = time spent with an oxygen saturation inferior to 90% of total sleeping time. NA = Not Applicable. Data are presented as Median ± MAD. p = p value following Student or Wilcoxon’s test; pa = p value adjusted for age and gender. *p ≤ 0.05; ***p ≤ 0.001.