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. 2017 Apr 20;7:45523. doi: 10.1038/srep45523

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Copyright © 2017, The Author(s)

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(a) Ectopic expression of YAP and YAP^S127A was detected by immunoblotting. (b) Nuclear expression of YAP was examined in YAP and YAP^S127A overexpressing cells. (c) Apoptotic cells and morphological changes were preliminarily observed by microscopic examination in YAP and YAP^S127A overexpressing cells 48 h after TGF-β1 treatment (10 ng/mL). Cells were imaged at 40× magnification. (d) The inhibition of TGF-β1-induced (10 ng/mL, 48 h) apoptosis by overexpression of YAP and YAP^S127A was detected by Annexin V/PI double staining. The statistic data shown are the means ± SD of three independent experiments. (e) The cleaved caspase-3 level was determined by immunoblotting in YAP and YAP^S127A overexpressing cells in response to TGF-β1 (10 ng/mL, 48 h).