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. 2017 Apr 20;7:46667. doi: 10.1038/srep46667

Figure 3. SUV39H1 and H3K9me3 levels are down-regulated in the lungs of COPD patients compared with control subjects.

Figure 3

(a) Expression of SUV39H1 was reduced in human small airway epithelial cells derived from COPD patients(COPD HSAEpC) compared with normal HSAEpC(NC). The SUV39H1 protein levels were measured by western blot analysis.(b) SUV39H1 or H3K9me3 levels in lung tissues of normal or COPD subjects were estimated by immunohistochemistry. Immunohistochemical staining of enlarged regions of the lungs of patients with COPD showing reduced SUV39H1(i vs iii) or H3K9me3(v vs vii) levels in epithelial cells compared with normal subjects. Moreover, the SUV39H1(ii vs iv) or H3K9me3(vi vs viii) levels were reduced in macrophages or interstitial mononuclear cells. Normal mouse IgG was used as a negative control for both IHC staining. An enlarged view of the rectangular region was drawn with dashed lines. Scale bar, 200 μm. **p < 0.01.