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. 2017 Apr 20;7:46667. doi: 10.1038/srep46667

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(a) The IL-8 protein levels were reduced in human small airway epithelial cells derived from COPD(COPD HSAEpCs) patients compared with normal HSAEpCs(NC). The levels of IL-8 in supernatants were measured by ELISA.(b) However, the IL-10 levels in COPD HSAEpCs were similar to in normal control cells.(c) The recruitment of SUV39H1 in the IL-8 gene promoter was reduced in COPD HSAEpCs compared with normal control. The enrichment of SUV39H1 was evaluated by chromatin immunoprecipitation(ChIP) analysis.(d) The enrichment of H3K9me3 in IL-8 gene promoter was also reduced in COPD HSAEpCs. All data are presented as the mean ± SEM of at least three independent experiments. **p < 0.01 and ***p < 0.001.