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. 2017 Apr 20;7:46667. doi: 10.1038/srep46667

Figure 7. SUV39H1 repression increases the inflammation response in cigarette smoke exposure mice.

Figure 7

(a) SUV39H1 or H3k9me3 levels were visualized by immunohistochemical staining in the lungs of cigarette smoke filtered control(normal), cigarette smoke exposure(smoking), or smoking combined with chaetocin administration(smoking/chaetocin) mice. Smoking and smoking/chaetocin mice displayed slightly and markedly reduced SUV39H1 expression in the epithelium compared with control mice, respectively. The H3K9me3 levels were also considerably decreased in smoking and smoking/chaetocin mice. Scale bar, 200 μm.(b) Western blot analysis of SUV39H1 or H3k9me3 showed a similar trend as the immunohistochemical staining results. The H3k9me3 levels were significantly reduced in smoking and smoking/chaetocin mice compared with control mice.(c) Chaetocin treatment accelerates the protein levels of a murine IL-8 homologue, KC, in the lung tissue induced by smoking. The KC expression of the smoking(gray bars) or smoking and chaetocin(black bars) treated mice(n = 6 animals per group) is depicted compared with control mice. *p < 0.05; **p < 0.01; and ***p < 0.001.