Table 4.

Novel Genetic and Epigenetic Markers of Adrenocortical Neoplasms in Normal and Neutered Male Mice and Ferrets.

Gene/Protein	Normal Expression and Function	Expression in Adrenal Neoplasms
Serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (Spinlw1)	Sertoli cells and epididymal cells	Upregulation of gene expression
Insulin-like 3 (Insl3)	Interstitial cells	Overexpression of protein
Forkhead box L2 (Foxs1)	Sertoli cells, periendothelial cells of testis, neural crest derivatives, and subcapsular adrenocortical cells	Promoter hypomethylation and gene overexpression