Table 5.

Novel Genetic and Epigenetic Markers of Adrenocortical Neoplasm in Normal and Neutered Female Mice and Ferrets.

Gene/Protein	Normal Expression and Function	Expression in Adrenal Neoplasms
Insulin-like 3 (Insl3)	Theca interna cells	Protein overexpression
Forkhead box L2 (FOXL2)	Interstitial and granulosa cells	Protein overexpression
Insulin related growth factor binding protein 6 (Igfbp6)	Somatic cells of ovary. IGFBP6 binds to IGF1 and 2 and plays vital roles in growth, function, and differentiation of adrenocortical cells	Promoter hypomethylation and gene upregulation