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. 2017 Apr 20;11:100. doi: 10.3389/fncel.2017.00100

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Copyright © 2017 Ju, Yang, Lei, Xia, Luo, Ji, Martynyuk and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of ketamine on the levels of DNA methyltransferases (DNMTs) in the medial prefrontal cortex (mPFC) and hippocampus (HIP) of IFS mice. (A) Representative blots of the protein levels in the six groups. (B) The DNMT1 had no significant difference among the six groups. (C,D) IFS led to the overexpression of DNMT3a and DNMT3b in the mPFC and HIP. Data are presented as mean ± SEM (n = 5 in per group). ***P < 0.001 compared with the Veh group; ^###P < 0.001 compared with the IFS + Veh group.