Table 1. Frequency of genomic alterations determined by CGH analysis in female ACI rat E₂-induced mammary tumors.

Chromosome	Genetic alteration	Region*	Locus*	Ratio†	Frequency, %	P value‡
1	q11-q22	1q21-22	Ccne1	7/11	63.6	0.017
4§	q41-q44	4q32-44	Ccnd2	7/11	63.6	0.005
7§	q31-q33	7q33	c-myc	9/11	81.9	0.005
9	q11-q13			6/11	54.5	0.056
11§	p-q11			6/11	54.5	0.056
13§	q			7/11	63.6	0.017
20§	p12			9/11	81.9	0.005

Eleven individual MTs were examined with an average of 10 metaphases per MT.

^*From Entrez Genome, Ratus norvegicus Map View (www.ncbi.nlm.nih.gov/mapview/maps.cgi).

^†Frequencies ≥30%.

^‡Analyzed by binomial distribution.

^§Chromosomal alterations identified by karyotype analysis.