Table 1.
IC50 Values (μM) of Kinase Inhibition and A431 Cytotoxicity Assay
| Compd # | VEGFR-2 (Flk-1) Kinase Inhibition | EGFR Kinase Inhibition | PDGFR-β Kinase Inhibition | A431 Cytotoxicity |
|---|---|---|---|---|
| 1 | 22.6±4.5 | 15.07±3.1 | 2.8±0.42 | 49.2±4.7 |
| 2 | 56.3±7.1 | 10.41±1.2 | 40.3±5.1 | 14.1±2.0 |
| 3 | 160.3±19.1 | 20.0±3.6 | 90.1±10.2 | 43.1±7.0 |
| 4 | 193.1±22.6 | 167.3±20.1 | 58.2±8.1 | >200 |
| 5 | 10.2 ±2.6 | 4.3±0.62 | >200 | 38.4±5.2 |
| 6 | 182.2±34.2 | 20.8±3.1 | 60.5±7.2 | 67.3±7.2 |
| 7 | >500 | 8.3±1.9 | >200 | 10.3±2.1 |
| Semaxanib | 12.0±2.7 | |||
| CB67645 (24) | 0.2±0.004 | |||
| DMBI | 3.7±0.06 | |||
| Cisplatin | 10.6±2.9 |